Founded in 1957 by the late Attorney Eugenio Millado and his wife, Doña Aurora Garcia-Millado, as Mindanao Vocational School (MVS). In 1960, MVS earned its college status and became Magsaysay Memorial Colleges (MMC). For the next few years, MMC added more undergraduate programs, opened departments in kindergarten, elementary education, secondary education and later acquired Southern Island Colleges (SIC).

In 1978, the late Honorable Florante Garcia-Millado, the only son of Attorney Eugenio Millado and Doña Aurora Garcia-Millado, became the college president. The school was renamed again in honor of the 7th President of the Philippines, Ramon Magsaysay.

Since 1993, Ramon Magsaysay Memorial Colleges (RMMC) has been succeeded by the wife of the Honorable Florante Garcia-Millado, Mrs. Regner-Millado, as the chairperson, alongside their four children as the appointed members of the board and corporate executive positions.